Stem Cell Therapy
At Sharlin Health Regeneration Center we offer stem cell therapy to those who seek treatment to help protect and aid in the repair of a disease-damaged brain and spinal cord. Rather than a drug, device, or a biological product, our technology harnesses the power of your own cells to do what they do naturally.
HOW DO STEM CELLS WORK?
Stem cells offer a wealth of potential for those with disease-related damage to their neurological system.While hope is on the way, the FDA currently has no approved option that can benefit those with neurological conditions. Only stem cells from umbilical cord blood have so far met the FDA’s approval with limited indication for use for treating patients with blood-related disorders.
For those who have done their research, the Food and Drug Administration has stated that the use of stem cells derived from fat, stem cell signaling molecules called exosomes, and the intravenous administration of stem cells, cannot be used unless part of an Institutional Review Board and FDA-sanctioned clinical trial. However, there’s another option: stem cells that come from your own bone marrow. These “medicinal signalling cells” can be delivered directly to the place of injury where they normally function.
Following strict guidelines we are able to offer this treatment to you.
Under conditions of injury or disease, the stem cells in our bone marrow migrate into their central nervous system. These cells help protect, repair, and regenerate the cells in the patient’s brain and spinal cord.
With stem cell therapy, we believe it is possible to stimulate the body’s innate ability to repair injured brain and spinal cord cells. Stem cells reduce neuro-inflammation, and slow or stop programmed cell death. As part of an overall treatment plan, stem cell therapy may play a key role in the management of a variety of neurological diseases, and help change the expected disease course.
NEUROLOGICAL TREATMENTS ON THE LEADING EDGE OF SCIENCE.
The Sharlin Health Regeneration Center’s protocol will give our patients the opportunity to use their own stem cells to help repair disease-damaged neural tissue.
This approach has the potential to change lives. Studies on both animals and humans indicate that stem cells can deliver nerve-growth factors to aid in the repair of injured neural tissue and modulate their immune systems, giving those who suffer from chronic conditions that affect the brain and spinal cord their best chance at a better quality of life. Research shows that introducing these autologous (patient-derived) stem cells is safe, with minimal side effects. Studies show that introducing these autologous (patient-derived) stem cells into their spinal fluid is safe, with minimal side effects.
Safety and Feasibility of Repeated Intrathecal Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells in Patients with Neurological Diseases.
Stem Cells Int. 2019 Jul 25;2019:8421281. doi: 10.1155/2019/8421281. PMID: 31428161; PMCID: PMC6683773. Mesenchymal stromal cells (MSCs) have become the most commonly used adult stem cells in regenerative medicine. Preclinical studies have shown that MSCs-based therapy is a potential new treatment approach for neurological diseases. Intrathecal injection has a unique feature which allows stem cells to directly migrate to the lesion site in patients with central nervous system (CNS) diseases. In this study, the highest adverse event was a slight ache at the injection site (4.11%), followed by fever (3.42%) and mild headache (2.05%). No severe adverse events were reported. Compared with previous studies, the incidence of adverse events was nearly consistent or even lower for headache, fever, nausea, and neck pain. In conclusion, repeated intrathecal allogeneic BM-MSCs are safe, feasible, and promising for the treatment of patients with neurological diseases.
Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis: Results of Phase 1/2 and 2a Clinical Trials.
JAMA Neurol. 2016 Mar;73(3):337-44. doi: 10.1001/jamaneurol.2015.4321. PMID: 26751635. Among the 12 patients in the phase 1/2 trial and the 14 patients in the phase 2a trial aged 20 and 75 years, the treatment was found to be safe and well tolerated over the study follow-up period. Most of the adverse effects were mild and transient, not including any treatment-related serious adverse event. The rate of progression of the forced vital capacity and of the ALS Functional Rating Scale-Revised score in the IT (or IT+IM)-treated patients was reduced (from -5.1% to -1.2%/month percentage predicted forced vital capacity, P < .04 and from -1.2 to 0.6 ALS Functional Rating Scale-Revised points/month, P = .052) during the 6 months following MSC-NTF cell transplantation vs the pretreatment period. Of these patients, 13 (87%) were defined as responders to either ALS Functional Rating Scale-Revised or forced vital capacity, having at least 25% improvement at 6 months after treatment in the slope of progression.
Phase I Trial of Intrathecal Mesenchymal Stem Cell-derived Neural Progenitors in Progressive Multiple Sclerosis.
EBioMedicine. 2018 Mar;29:23-30. doi: 10.1016/j.ebiom.2018.02.002. Epub 2018 Feb 3. PMID: 29449193; PMCID: PMC5925446. We conducted a phase I open-label clinical trial investigating the safety and tolerability of autologous bone marrow mesenchymal stem cell-derived neural progenitor (MSC-NP) treatment in 20 patients with progressive MS. IT MSC-NP treatment was safe and well tolerated. The 20 enrolled subjects completed all 60 planned treatments without serious adverse effects. Minor adverse events included transient fever and mild headaches usually resolving in <24 h. Post-treatment disability score analysis demonstrated improved median EDSS suggesting possible efficacy.
Beneficial effects of autologous mesenchyma l stem cell transplantation in active progressive multiple sclerosis.
Brain. 2020 Dec 1;143(12):3574-3588. doi: 10.1093/brain/awaa333. PMID: 33253391. Treatment with MSCs was well-tolerated in progressive multiple sclerosis and induced short-term beneficial effects regarding the primary end points, especially in the patients with active disease. The intrathecal administration was more efficacious than the intravenous in several parameters of the disease.
Mesenchymal Stem Cell Therapy and Alzheimer's Disease: Current Status and Future Perspectives.
J Alzheimers Dis. 2020;77(1):1-14. doi: 10.3233/JAD-200219. PMID: 32741816. This review describes the latest research trends on the use of MSC-based therapies in AD and its mechanism of action. MSCs have several beneficial effects. They would be specified as the reduction of neuroinflammation, the elimination of amyloid-β, neurofibrillary tangles, and abnormal protein degradation, the promotion of autophagy-associated and blood-brain barrier recoveries, the upregulation of acetylcholine levels, improved cognition, and the recovery of mitochondrial transport.
Mesenchymal Stem Cells as a Source of Dopaminergic Neurons: A Potential Cell Based Therapy for Parkinson's Disease.
Curr Stem Cell Res Ther. 2017;12(4):326-347. doi: 10.2174/1574888X12666161114122059. PMID: 27842480. Mesenchymal stem cells are an attractive therapeutic candidate because of their high capacity for self-renewability, no adverse effect to allogeneic versus autologous transplants, high ethical acceptance and no teratoma formation. Therefore, mesenchymal stem cells can be considered as an ideal source for replacing lost cells in degenerative diseases like Parkinson's. Hence, the use of these cells in the differentiation of dopaminergic neurons becomes significant and thrives as a therapeutic approach to treat Parkinson's disease.
Sharlin Health Regeneration Center’s goal is to provide patients an option for the use of stem cells to aid in the protection and repair of the brain and spinal cord.
Our proprietary stem cell safe treatment represents a breakthrough for those seeking this type of care.
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